Mixing XXI - Technical program

A group of experts will discuss and review the role of mixing in the batch manufacture of pharmaceuticals and other fine chemicals. The special problems associated with these type of operations will be reviewed including the role of regulation, peculiar equipment configurations, special effects of non-optimum equipment on process results and scale up and some special case studies. There will be four presenters from academia, consulting and industry.

2:00 – 4:00 pm

Alpine Conference Room

NAMF Council Meeting

1:00 – 4:00 pm

Kearns Room

Exhibit Set-up

2:00 – 6:00 pm

Lobby

REGISTRATION

4:30 – 7:30 pm

Kearns Room for Exhibit

WELCOME RECEPTION, EXHIBIT, AND WESTERN BBQ

7:30 – 10:00 pm Summit AB	SESSION 1: FUNDAMENTALS OF MIXING TECHNOLOGY & MIXING EDUCATION Co-Chairs: Chad Bennington and Midey Chang-Mateu
7:30 pm	Opening Comments From Conference Chairs Hanh Vo, Dow Corning Corporation; and Kathy Barton, Lake Forest Academy
7:35 pm	Process Design Elements of Agitated Columns Julian Fasano, Mixer Engineering Company.
8 :00 pm	Diffusion Confusion E. B. Nauman, Rensselaer Polytechnic Institute
8:25 pm	Simulation of Free Surface Flow in the Mixing Zone of an Annular Centrifugal Contactor Kent E. Wardle, Todd R. Allen, Mark H. Anderson, and Ross Swaney, University of Wisconsin--Madison
8:50 pm	Break
9:05 pm	Panel Discussion on Mixing and Education – Current State and NAMF’s Role Led by Art Etchells with Bruce Nauman, Dave Dickey, Tom Simpson and Suzanne Kresta as panelists
10:00 – 11:30 pm Mountain View and Kearns Rooms	SOCIAL HOUR AND EXHIBIT

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MONDAY

7:00 – 8:00 am Summit C	Breakfast
8:00 am – noon Summit AB	SESSION 2: NOVEL EXPERIMENTAL METHODS Co-Chairs: Dave Dickey and Suzanne Kresta
8:00 am	INVITED PLENARY Oscillations of Primary Circulation Loop of Agitated Liquid in a System with Pitched Blade Impeller Ivan Fort, Tomas Bruha, Oldrich Bruha, Milan Jahoda, and Pavel Hasal, Czech Technical University in Prague
9:00 am	Use Of A High Speed Video System For The Characterization Of Multiphase Dispersions Eliane Guevara, María Soledad Córdova, Gabriel Corkidi and Enrique Galindo, Universidad Nacional Autónoma de Mexico.
9:25 am	On-Line Monitoring Of Crystallisation By Electrical Tomography As An Aid To Process Understanding, Scale-Up And Control Ken Primrose, Industrial Tomography Systems Ltd, UK
9:50 am	Break
10:20 am	Mixing Time for Liquid-Supercritical Phase Transition of n-Hexadecane-CO₂ Mixtures G. Anitescu, R. Lin and L.L. Tavlarides, Syracuse University
10:45 am	CFD Modeling of Mixing In 5-Liter Laboratory Flask Arthur Kravchenko, I-Hwa Midey Chang-Mateu, Rohm and Haas Company
11:10 am	Designing of Impeller Properties Chris Hibshman, Wojciech Wyczalkowski, Philadelphia Mixing Solutions, LTD
11:35 am	An In-Depth Assessment of the Measurement of Turbulent Mixing in a Vessel Stirred by a Rushton Turbine using Positron Emission Particle Tracking (PEPT) and its Comparison with PIV and Particle Tracking using CFD Fabio Chiti, Serafim Bakalis, Waldemar Bujalski, Alvin W. Nienow, Mostafa Barigou; University of Birmingham, UK; and Archie Eaglesham, Huntsman Polyurethanes, Belgium
noon – 1:00 pm Summit C	Lunch
5:00 – 5:40 pm	SOCIAL HOUR AND EXHIBIT Mountain View and Kearns

5:40 – 7:00 pm	DINNER, Summit C
7:00 – 10:00 pm Summit AB	SESSION 3: STATIC MIXERS AND OTHER IN-LINE MIXERS Co-Chairs: Julian Fasano and John Middleton
7:00 pm	CFD Modelling of Nano-Particle Clusters Break-Up In High-Shear Devices Jerzy Baldyga, Wojciech Orciuch, Lukasz Makowski, Marek Henczka, Maciej Malski-Brodzicki and Katarzyna Malik, Warsaw University of Technology, Poland
7:25 pm	Re-Dispersion Microreactor for The Formation of Liquid-Liquid Dispersions for Use In Polycondensation Sonja Rothstock, Prasad Jadhavrao, Patrick Löb, Karl-Peter Schelhaas, Bernd Werner, Inst. für Mikrotechnik Mainz GmbH, Chem.Prozeßtechnik, Univ. of Technology, Dept. of Chem. Eng.& Chemistry; and David Agar, University of Dortmund, Bio- u. Chemieingenieurwesen, Germany
7:50 pm	FMPSG/IChemE Student Competition Winner Stereoscopic PIV study of the flow field generated by a sawtooth impeller Heema Unadkat, Loughborough University, UK
8:15 pm	Break
8:45 pm	Mixing in a Multi-Inlet Vortex Mixer (MIVM) for Flash NanoPrecipitation Ying Liu, Robert K. Prud’homme, Princeton University; and Chungyin Cheng, Ying Liu, and Rodney O. Fox, Iowa State University
9:10 pm	Flow And Mixing Characterization Of A Static Mixer Using Laser-Doppler Anemometry And Simultaneous Particle-Image - Velocimetry/Planar Laser-Induced Fluorescence Stefan Leschka, Dominique Thévenin, Katharina Zähringer, Lehrstuhl Strö-mungsmechanik & Strömungstechnik, Inst. für Strömungstechnik & Thermodynamik, Otto-von-Guericke, Universität Magdeburg, Germany
9:35 pm	Development of Plate Static Micromixer to Generate Multilamination of Fluid Layers by Splitting, 180-degree rotation and Recombination Yushi Hirata, Yoshiro Inoue, Division of Chem. Engineering, Grad.School of Eng. Science, Osaka University, Japan; and Kazuo Ohkawa, Process Chemistry Laboratories, Astellas Pharma Co., Ltd, Japan
10:00 – 11:30 pm	SOCIAL HOUR AND EXHIBIT Mountain View and Kearns

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TUESDAY

7:00 – 8:00 am Summit C	Breakfast
8:00 am – noon Summit AB	SESSION 4: MIXING AND REACTION Co-Chairs: Otute Akiti and Victor Atiemo-Obeng
8:00 am	INVITED PLENARY Mixing & Reaction - What Happened Next? John Bourne, Retired Professor, Chemistry Department, ETH, Zurich
9:00 am	Effects Of Feed Pipe Backmixing on Micromixing: An Experimental Study Suat Peng Lee, Melissa Assirelli (speaker), Institute of Chemical and Engineering Sciences, Singapore; and Alvin W. Nienow, University of Birmingham, UK
9:25 am	NAMF Student Finalist Modeling a pilot-scale pulp mixing chest using CFD Clara Ford, Chad P.J. Bennington and Fariborz Taghipour, University of British Columbia, Vancouver, Canada
9:50 am	Break
10:20 am	Bubble Sizes in Agitated Water-Hydrophilic Organic Solvents for Heterogeneous Catalytic Hydrogenation Reactions: Simultaneous Bubble Size and Reaction Rate Measurement Alvin W. Nienow (speaker), Binjie Hu, Andrzej W. Pacek, J. Michael Winterbottom, Robert P. Fishwick, University of Birmingham, UK; and Hugh Stitt, Johnson Matthey Catalysts, UK
10:45 am	Realities of Process Intensification for Reactors John Middleton, BHR Group, UK
11:10 am	NAMF Student Finalist: Controlling Nanoparticle Agglomeration in a Confined Impinging Jet Reactor Shad W. Siddiqui, Peter Unwin, and Suzanne Kresta, University of Alberta, Canada
11:35 am	Review of Shortcut Closure Methods for Estimating Conversion and Yield in Mixed Reactors Gary K. Patterson, University of Missouri-Rolla, Rolla
Noon – 1:00 pm Summit C	Lunch

4:30 – 5:40 pm Mountain View, Kearns and Ivans/Hearst	SOCIAL HOUR AND EXHIBIT
5:40 – 7:00 pm Summit C	DINNER
7:00-10:00 pm	SESSION 5: VISCOUS AND NON-NEWTONIAN MIXING Co-Chairs: Piero Armenante and Dave Brown
7:00 pm	Spacial Statistics, Segregation and Definitions of Well Mixed Alena Kukukova, Joelle Aubin and Suzanne M Kresta, University of Alberta; Canada
7:25 pm	Laminar Mixing In Baffled And Unbaffled Tanks Using Central And Off-Centre Impeller Geometries J F Hall , M J H Simmons, E H Stitt, and M Barigou, Johnson Matthey Technology Centre UK, Dept. Formulation Engineering, University of Birmingham, Edgbaston, UK
7:50 pm	Engineering Fundamentals of Reactive Extrusion David Todd, Polymer Processing Institute, New Jersey Institute of Technology
8:15 pm	Break
8:45 pm	Dynamics of Pulp Stock Mixing Chests Chad P.J. Bennington, University of British Columbia, Canada
9:10 pm	Automation Of Non-Newtonian Blending Simulations - Building A Bridge From The Virtual World To The Process Engineer William Hartt, Krista Comstock, Hua Hu, Tim Laska, Mark Whaley, Samantha Bibart; David Peterson & Eric Jones, The Procter and Gamble Company & Enthought, Inc.
9:35 pm	*Comparison of The mixing Performance of SHI's MAXBLENDwith Ekato's PARAVISC, Co-axial Impellers and Standard Dual Open Impellers.* Philippe Tanguy, URPEI-TOTAL Chair, École Polytechnique, Montréal, Canada Luciana Rudolph, Dow Olefinverbund GmbH, Merseburg, Germany, and Victor Atiemo-Obeng, The Dow Chemical Company, Midland Michigan
10:00 – 11:30 pm Mountain View and Kearns	SOCIAL HOUR AND EXHIBIT

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WEDNESDAY

7:00 – 8:00 am	Breakfast / Summit C
8:00 am – noon	SESSION 6: INDUSTRIAL MIXING Session Chairs: Richard Cope and Roy Penney
8:00 am	Opening Comments to Dedicate This Session to Jim Oldshue Tom Post, Post Mixing, NY
8:10 am	The Effect of Reactor Mixing Equipment on Shear-Induced Agglomeration Paul Gillis, John Blythe and Cesar Gonzalez, Dow Chemical - Midland
8:35 am	Uniform Suspensions of Slow Settling Solids – Scale Up of Dispensing Tanks Equipped with Bottom-Mounted, Magnetic-Coupled Mixers Eric Ricci and Billy R. Allen, Eli Lilly and Company
9:00 am	Why Mixers Fail? Todd Hutchinson, Wojciech Wyczalkowski, Philadelphia Mixing Solutions LTD
9:25 am	Mixing in Sanitary Systems by Rotary Jet Heads: Fundamentals and Applications Mikkel Nordkvist and John Åge Lazar, ISO-MIX A/S, Denmark; Alvin Nienow, University of Birmingham, UK; and John Villadsen, Technical University of Denmark, Denmark
9:50 am	Break
10:20 am	Liquid-Liquid Suspension in Agitated Vessels: An Experimental and Correlational Study W. Roy Penney, Timothy B. Jones, Melissa A. Myrick, Pamela I. Popejoy, Ricky W. Goff, University of Arkansas.
10:45 am	New Advances in Mixing Technology for World Scale Reactors Werner Himmelsbach and David Houlton, EKATO RMT, Germany; and Mark Lovallo, EKATO Corporation, USA
11:10 am	Solid Suspension and Distribution Studies with Single and Twin Impellers David Brown and Chris Hampson, BHR Group Limited, UK; and Kishore K. Kar, Richard F. Cope, Susan M. Kling and Kim A. James, The Dow Chemical Company, USA
11:35 am	Introduction of posters (2 minutes for each poster) Chair: Shaffiq Jaffer
Noon	Call for nominations for NAMF Council
12:10 – 1:10 pm	Lunch / Summit C
4:30 – 5:40 pm	POSTER SESSION, SOCIAL HOUR AND EX HIBIT Poster Room: Mountain View, Kearns and Ivans/Hearst
P1 Emulsification Characterization Of A Dual-Shaft Mixer Avinash R. Khopkar, Louis Fradette and Philippe A. Tanguy, Ecole Polytechnique, Canada P2 Mixing Software Development: The FMP Excel Design Guide David Brown, Sat Panesar , BHR Group, UK P3 Experimental Study of Macro-scale Mixing in a Scale-Model Agitated Pulp Stock Chest using PIV Clara Ford, Chad P.J. Bennington and Fariborz Taghipour, The University of British Columbia Vancouver, Canada P4 Mixing in Large Petroleum Storage Vessels Chris Hastings and Woiciech Wyczalkowski, Philadelphia mixing Solutions, LTD P5 Predicting k_La From Correlations John Middleton, BHR Group, UK P6 Novel Propeller Design Optimized For Mixing Employing Circular Rake, Helical, Parabolic Camber, and Skewed Blade Design Concepts Robert W, Higbee, Wojciech Wyczalkowski; Philadelphia Mixing Solutions Ltd. P7 Simulation of Micromixing in Turbulent Tubular Reactors with Unmixed Feed Pradyumna Kumar Parida and D. Phaneswara Rao, Indian Institute of Technology, India P8 Oil And Air Dispersion By Rushton And Smith Impellers Measured With High Speed Digital Video Eliane Guevara, María Soledad Córdova and Enrique Galindo , Universidad Nacional Autónoma de Mexico, MEXICO P9 Mass Transfer Characteristics by Surface Aeration of Large Paddle Impeller: Application to Polymerization Reactor with Liquid Level Change Ryuichi YATOMI, Katsuhide TAKENAKA, SHI Mechanical & Equipment INC. (Sumitomo Heavy Industries Group), Japan; Koji TAKAHASHI, Yamagata University, Japan; and Philippe A. TANGUY, Ecole Polytechnique, Canada P10 Cavern Formation in Agitated Pulp Suspensions Leo Hui, Chad P.J. Bennington and Guy A. Dumont, University of British Columbia Vancouver, Canada P11 An Optimum Design for a Low Shear Hydrofoil Impeller through The Use of an Optimization Model Coupled With Computational Fluid Dynamics (CFD) N. Spogis, INTERNATIONAL TRADE CENTER , Brazil; and J. R. Nunhez; Universidade Estadual de Campinas, Brazil P12 Novel High Purity Oxygen Delivery System for Waste Water Applications Larry Coleman, Praxair; and Wojciech Wyczalkowski, Philadelphia mixing Solutions, LTD P13 Evaluation of Pulp Stock Chest Mixing Performance Ali Soltanzadeh, Guy A. Dumont, and Chad P.J. Bennington, University of British Columbia Vancouver, Canada
5:40 – 7:00 pm	DINNER / Summit C

7:00 – 10:00 pm Summit AB	SESSION 7: CFD VERIFICATION AND VALIDATION Co-Chairs: Phil Smith and Jennifer Spinti
7:00 pm	The Pedagogy of Verification and Validation for Simulation Science of Mixing Processes Philip J. Smith, University of Utah
7:25 pm	Validation of Mixing and Reaction Models For Sooting Nonpremixed Turbulent Flames Using Direct Numerical Simulation David Lignell, Sandia National Laboratories (California)
7:50 pm	Experimental and Computational Comparisons of the Hydrodynamics in Two Differently Bottomed Partially Baffled Stirred Tank Reactor Systems Equipped with a Retreat Blade Impeller Giuseppe Di Benedetto and Piero M. Armenante, New Jersey Institute of Technology
8:15 pm	Break
8:45 pm	Validation of Turbulent Mixing in a Large Eddy Simulation of a Buoyant Helium Plume J. Thornock, Z. Gao, S. Borodai, J. P. Spinti, and P. J. Smith, University of Utah
9:10 pm	Validating CFD Models for Slurry Mixing Using Pulse-Jet Mixers Brigette Rosendall, Chris Barringer, Feng Wen, Bechtel National, Inc. San Francisco, CA
9:35 pm	Influence of Merging, Parallel and Diverging Flow Patterns on Gas-Liquid Flows in a Tall Stirred Vessel: Some numerical experiments Avinash R. Khopkar and Philippe A. Tanguy, Ecole Polytechnique, Canada
10:00 – 11:30 pm Mountain View and Kearns	SOCIAL HOUR AND EXHIBIT

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THURSDAY

7:00 – 8:30 am	Breakfast / Summit C
8:00 am – 12:10 pm Summit AB	SESSION 8: MULTIPHASE MIXING Co-Chairs: Richard Calabrese and Enrique Galindo
8:00 am	Emulsions and Emulsification: Status and Future Challenges Shaffiq Jaffer, The Procter and Gamble Company; and Alvin Nienow, University of Birmingham, UK
8:40 am	Turbulent Liquid-Liquid Dispersions Jos Derksen and Harry van den Akker, Delft University of Technology, Netherlands
9:05 am	NAMF Student Finalist: Gas-Liquid Mass Transfer In Unbaffled Dual-Impeller Mixers Francois Cabaret, Louis Fradette and Philippe A. Tanguy, URPEI, Department of Chemical Engineering, Ecole Polytechnique, Montreal, Canada
9:30 am	A Comparison of Traditional Rushton Disc Turbines with High Solidity Ratio, Up-pumping, Axial Hydrofoil Impellers in 550 L Pilot Scale Aerobic Submerged Fermentations Stuart M Stocks, Novozymes A/S, Denmark; and Alvin W. Nienow, University of Birmingham, UK
9:55 am	Break
10:20 am	Energy And Mass Transfer In Dispersed Gas-Liquid Reactors John M Smith, University of Surrey, UK
10:45 am	Particle Tracking Simulations in an Inline Rotor-Stator Mixer to Aid in the Prediction of Drop Size Distribution Karl R. Kevala, Kenneth T. Kiger and Richard V. Calabrese, University of Maryland
11:10 am	Solids Suspension Using Unbaffled Angled Agitation Jonathan P. Herr and Kevin J. Myers & Eric E. Janz and Joel D. Duvall and Julian B. Fasano, University of Dayton, Chemineer, Inc and Mixer Engineering Co
11:35 am	Intensifying Inter-phase Mass Transfer in Air Lift Reactors Handling Industrial Streams A.M. Al Taweel, S. K. Pallapothu, H.G. Gomaa and A. Ghanem, Dalhousie University, Halifax NS, Canada
12:00	NAMF Council Election Ballot
12:10 – 1:10 pm	Lunch / Summit C

4:30 – 5:30 pm Summit AB	NAMF GENERAL MEETING
5:30 – 6:00 pm Mountain View and Kearns	SOCIAL HOUR AND EXHIBIT
6:00-7:30 pm Summit AB	AWARDS DINNER
7:45 – 10:00 pm Summit AB	SESSION 9: TO HONOR/ COMMEMORATE JIM OLDSHUE Session Chairs: Larry Tavlarides and Ron Weetman
7:45 pm	Opening Remark Ron Weetman, RJWeetman.com
7:50 pm	Mixer Design and Operating Issues in Sufuric Acid Catalyzed Alkylation Reactors Ramesh Hemrajani, Mixing & Reactor Solutions
8:15 pm	Optimization Of Mixing In Agitated Horizontal Tank Reactors Tom Post, Darryn McClelland, Keith Johnson, and Herman Pieterse, Post Mixing, NY
8:40 pm	Mechanical Scale-up and Problems of Mixing Systems Ronald J. Weetman, RJWeetman.com, Paul Kubera, ABEC, Inc.; Gerry Dubois, STI Technologies, Inc.; and Mac Kendall, Biogen Idec
9:05 pm	Break
9:20 pm	Slide Show And Presentations To Celebrate Jim Oldshue’s Life And His Many Contributions To Mixing And Other Areas Ron Weetman, RJWeetman.com ; Bernie Gigas, Lightnin, and other individuals
10:00 – 11:30 pm Mountain View and Kearns	SOCIAL HOUR AND EXHIBIT